G-RAY is a Swiss private company focused on the development and commercialisation of particle detectors and related services for medical imaging. Its collaboration with CERN provides the opportunity to explore the performance of low-temperature bonding processes using established characterisation techniques and expertise relating to microelectronics, microfabrication, microsystems engineering, advanced interconncets, and detector development. The investigation of low-temperature direct bonding of epitaxial Si to CMOS Front-End read-out electronics may provide an interesting solution for the development of monolithic detectors in the field of high-energy physics. Ultimately, this could improve the performance of medical imaging particle detectors.